The Nightmare Crew is on the hunt for their evil genius creator, but they find trouble that could spell the end of them all. Paul Wiseman and his crew return to battle their greatest opponents yet—versions of themselves. Paul has been transformed into a werewolf, and along with his girlfriend and the rest of the crew—a vampire, a sentient water being and a resurrected zombie—he moves out to the west coast to set up shop in the Sierra Madre mountain area in order to fight crime. They also seek more information on Andres Peterson, a ruthless and clever industrialist scientist, whose company made them. Peterson has fashioned his own version of the crew, but their methods of fighting crime are heavy-handed, cruel and unjust. Things are never as they seem, and it will take a death and a winner-takes-all fight to settle it. Will evil triumph?

Facing off against an old enemy isn't without repercussions. Paul and the Nightmare Crew take on not only their most dangerous adversary but also the establishment. Paul Wiseman and the rest of the Nightmare Crew attempt to fit into society as best they can. It isn't easy if you're a werewolf, a vampire or if you're a being made of water or sand. Along with failed efforts at integration comes the news that Andres Peterson, founder of Rallan, Inc.—the company that created the original Nightmare Crew—is still at large. Peterson is now a mutant, irretrievably evil, and he is also quite clever. With his genius, he sets about making a virtually limitless army of scientific horrors, and they begin to unleash terror on the populace. It's up to Paul and the rest of the crew to stop him. Along the way, they are joined by a young girl, who has powers of her own, and a group of Army Rangers. Catching Peterson is harder than any of them...

Paul Wiseman, orphan and runaway, was looking for a family. He found one—and got a little more than he bargained for in the process. Being an orphan is no fun. Having no friends isn't much fun, either. When Paul Wiseman, seventeen, runs away from an orphanage to try his luck on the mean streets of New York, he finds himself trapped and almost beaten to death one night. Rescued by a vampire named Angela, Paul goes to her small house in upstate New York where he meets her friends—Ooze, a sentient water being, Sandstorm, who uses his sandy body to blind his opponents, and CF—short for Cannon Fodder—a zombie. The four of them become the Nightmare Crew—beings created by a scientist to fight against the lawless elements of the city. In joining them, Paul finds a family, friendship and maybe even love. However, the company that allowed the creation of these beings wants them back, and they'll stop at nothing to retrieve...

Harry Goldman, teenage DNA researcher, genius, and total nerd, is thrown into jail for illegal transgenic research. Freed by the FBI on the condition he works under their aegis, Harry is taken to New York where he meets Anastasia, a cat-girl and the product of transgenic engineering. No sooner do they get acquainted then they are attacked by another creature, a bear which is more than a bear, and are forced to flee for their lives. Along the way, they encounter furries, Doug the Dog, find out that they are more into each other emotionally than they're willing to admit, and end up in the Catskill Mountains where Harry finds out the shocking truth about how Anastasia was created...and what she was created for.

Harry and Anastasia are expecting their first child, but there are forces in the world that do not and never will accept Harry's kind. Transgenics frighten people, and in a bid to win over public opinion, Harry puts his best foot forward.However, other forces are at work. Allenby, a mad scientist, is still alive and out to reshape humanity to his whims. Government officials also stand in the way of societal acceptance.Added into the mix are the arrival of some new transgenic creations, and Harry is forced once again to take them on with the help of Pavel, a Russian dog-demon, and bring the fight to one of the coldest regions in Russia. For his wife's sake as well as his daughter's sake, this is one fight Harry intends to win.

Harry and Anastasia are back, this time married and attempting to fit into society. When another transgenic emerges—a mole-man named Leonardo—he tells them an old friend, Istvan, a pig-man, long thought dead, is still alive.Doing the right thing, Harry and Anastasia go to investigate and find out other transgenics are alive, well, and led by yet another madman, bent on destruction. The trail begins in Italy, and continues on to France, Spain, and finally back to the United States.As if that wasn't enough, Anastasia is pregnant and Harry has to worry about her, the baby, and the plans of the madman who hates all transgenics and wants to see them eliminated. Anastasia's life is threatened as is the life of her baby, and with the outcome far from certain, the quest continues.

"I told you, don't call me Miss Kitty." Harry Goldman, young genius, DNA researcher and still a nerd, is back, and this time he's working for the law. At the end of Catnip, his girlfriend, Anastasia, devolved into a cat. He manages to bring her back to her half-human form, but no sooner does he do so than a new problem surfaces. Two other transgenics emerge, and they are out for blood. Harry and Anastasia have to face off against Lyudmila, another cat-girl, and Piotr, a half-rhino, half-boar monstrosity that lives to kill. And if that isn't bad enough, the police, lynch mobs, and underground dwellers are after Harry and his girlfriend as well. With time running out, they embark on a treacherous journey to the Ukraine in order to solve the riddle of Anastasia's DNA, a journey that could also cost both of them their lives.

Living on the edge of society isn’t the life for anyone. If the government has its way, Mitch Kessler and his enhanced friends won’t have any lives at all. Mitch Kessler, teenage high school dropout, jobless and mostly friendless, lives a life of solitude, but not by choice. Endowed with the ability to bring wings out of his body as well as claws, and transform himself into a fierce creature of the night, he’s picked up a nickname from the general public that he hates: gargoyle. However, that’s the least of his worries. His girlfriend, Callie, can’t keep her genders straight, his best friend is a spinning top, and his other acquaintance is made of rock. It’s obviously a government plot, but Mitch doesn’t know who’s behind it or why. Worse, various and sundry creations have now appeared out of the woodwork and are out to kill him. Aided by his friends, the four outcasts attempt to find out who’s running the show. They’re out to stop the forces of evil before they can do more damage. That is, if they survive.

Harry Goldman is back once more, and this time he's living the domestic life up in the Catskill Mountains with Anastasia, his transgenic girlfriend. At the end of Catnip 2: Rise of the Transgenics, he went through the same process as Anastasia did. Now he's the same as she is, and their only wish is to be left alone and to live their lives in peace.Their peace is shattered by the arrival of a pig-man named Istvan. It seems that Istvan escaped from a laboratory in Hungary where yet another scientist was conducting transgenic experiments. In short order, the young couple is confronted by Szabo, a giant of a man who is more shark than man. He has plans not only for himself but also for others who wish to become as he is.This is something that Harry cannot allow. Soon he, Anastasia and Istvan are circling the globe and making stops in Hungary and Serbia. Their journey ends in Russia where it all began. There, Harry meets the real brains behind the transgenics program and is once more...