From the acclaimed author of Miracle Cure and The Third Horseman, the epic story of the collision between one of nature's smallest organisms and history's mightiest empire During the golden age of the Roman Empire, Emperor Justinian reigned over a territory that stretched from Italy to North Africa. It was the zenith of his achievements and the last of them. In 542 AD, the bubonic plague struck. In weeks, the glorious classical world of Justinian had been plunged into the medieval and modern Europe was born. At its height, five thousand people died every day in Constantinople. Cities were completely depopulated. It was the first pandemic the world had ever known and it left its indelible mark: when the plague finally ended, more than 25 million people were dead. Weaving together history, microbiology, ecology, jurisprudence, theology, and epidemiology, Justinian's Flea is a unique and sweeping account of the little known event that changed the...

The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma.As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our...

How a seven-year cycle of rain, cold, disease, and warfare created the worst famine in European history In May of 1315, it started to rain. It didn't stop anywhere in north Europe until Au­gust. Next came the coldest winters in a millennium. Two separate animal epidem­ics killed nearly eighty percent of northern Europe's livestock. Wars between Scotland and England, France and Flanders, and two rival claimants to the Holy Roman Empire destroyed all remaining farmland. After seven years, the combination of lost harvests, warfare, and pestilence would claim six million lives—one eighth of Eu­rope's total population. William Rosen draws on a wide ar­ray of disciplines, from military history to feudal law to agricultural economics and climatology to trace the succession of traumas that caused the Great Famine. With dramatic appearances by Scotland's William Wallace, a luckless Edward II and his Queen Isabella, the onetime French princess who invaded...